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Medchemexpress LLC DBCO-NH-Boc | 1539290-74-8 | C₂₃H₂₄N₂O₃ | 25 MG
Supplier: Medchemexpress LLC 25MGHY140293
DBCO-NH-Boc is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It is a click chemistry reagent containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs are composed of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation.
- Alkyl/ether-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC)
- Used in the synthesis of PROTACs
- Enables selective protein degradation via the ubiquitin-proteasome system
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