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Medchemexpress LLC Dbco-peg2-acid | 2304558-25-4 | ≥95.0% | C26H28N2O6 | 100 MG
Supplier: Medchemexpress LLC HY140266100MG
DBCO-PEG2-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain Azide groups. PROTACs themselves are composed of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker.
- Utilized in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- PROTACs degrade target proteins via the ubiquitin-proteasome system.
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