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Medchemexpress LLC Dbco-peg2-val-cit-pab-mmae | 2845934-59-8 | MFCD35133151 | 99.3% | 1569.92 | C84H120N12O17 | 50 MG
Supplier: Medchemexpress LLC HY17228750MG
DBCO-PEG2-Val-Cit-PAB-MMAE is a cleavable antibody-drug conjugate (ADC) linker that combines a DBCO strain-promoted alkyne handle, a short PEG2 spacer, a protease-cleavable Val-Cit dipeptide, a para-aminobenzyl (PAB) self-immolative spacer, and an MMAE cytotoxic payload. It is intended for research use in ADC synthesis and click-chemistry conjugation.
- cleavable Val-Cit dipeptide for protease-triggered payload release.
- dbco click handle enables copper-free SPAAC conjugation to azides.
- peg2 spacer provides linker flexibility and solubility.
- para-aminobenzyl (PAB) self-immolative spacer facilitates payload release.
- includes a potent MMAE payload for cytotoxic activity in ADC constructs.
- supplied as a 50 mg package for laboratory research use.
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