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Medchemexpress LLC Dbco-peg4-nhs ester | 1427004-19-0 | 99.00% | C34H39N3O10 | 100 MG
Supplier: Medchemexpress LLC HY140272100MG
DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent contains a DBCO group, enabling it to undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs themselves consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting a specific protein, thereby exploiting the intracellular ubiquitin-proteasome system for selective protein degradation.
- Can be used in the synthesis of PROTACs.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition.
- Exploits the intracellular ubiquitin-proteasome system.
- Enables selective degradation of target proteins.
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