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Medchemexpress LLC DBCO-PEG4-Val-Cit-PAB-PNP | 2226472-28-0 | 98.3% | 1079.16 g·mol⁻1 | C55H66N8O15 | 25 MG
Supplier: Medchemexpress LLC HYW19091325MG
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker that integrates a dibenzocyclooctyne (DBCO) click handle, a four-unit PEG spacer, and a Val-Cit protease-cleavable dipeptide with a PAB-PNP leaving group. It is designed for strain-promoted azide-alkyne conjugation and for intracellular payload release following enzymatic cleavage, supporting ADC synthesis and other bioconjugation applications.
- Enables copper-free click conjugation to azide-containing molecules.
- Four-unit PEG spacer improves solubility and reduces steric hindrance.
- Val-Cit dipeptide is cleavable by Cathepsin B for intracellular payload release.
- PAB-PNP leaving group facilitates efficient payload attachment and release.
- High purity suitable for synthetic and analytical workflows.
- Stable storage and handling conditions support reproducible conjugation.
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