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Medchemexpress LLC Dbco-peg4-vc-pab-mmae | 2129164-91-4 | 99.2% | 1658.03 | C88H128N12O19 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY13631410MG

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DBCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) synthesis. The molecule combines a DBCO click-functional group, a PEG4 spacer, a valine-citrulline (Val-Cit) cleavable linker with a para-aminobenzyl (PAB) spacer, and the cytotoxic payload monomethyl auristatin E (MMAE). It is supplied as a powder for research use only.

  • Enables strain-promoted alkyne-azide cycloaddition (SPAAC) to azide-containing biomolecules.
  • Hydrophilic PEG4 spacer improves solubility and reduces aggregation.
  • Val-Cit-PAB linker is cleavable under lysosomal conditions for payload release.
  • High purity suitable for conjugation workflows.
  • Soluble in DMSO at 150 mg/mL; may require ultrasonic treatment.
  • Store as powder at -20°C for optimal stability.

Catalog No. 50-002-03951


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