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Medchemexpress LLC DBCO-PEG9-amine | 2353409-99-9 | 95.0% | C39H57N3O11 | 25 MG
Supplier: Medchemexpress LLC 25MGHY140285
DBCO-PEG9-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs themselves consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein intended for degradation. They operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains a DBCO group for SPAAC reactions
- Facilitates strain-promoted alkyne-azide cycloaddition with azide groups
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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