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Apexbio Technology LLC DCPIB 82749-70-0 50mg
Supplier: Apexbio Technology LLC B678050
DCPIB (CAS 82749-70-0) is a small molecule inhibitor of volume-regulated anion channels (VRAC) exhibiting an IC50 of 2 M in rat pancreatic -cells It also blocks swelling-induced chloride currents (ICl swell) in cardiovascular models with an IC50 of 4 1 M in CPAE cells In -cells DCPIB suppresses glucose-stimulated insulin secretion by VRAC inhibition and indirectly enhances KATP channel activity Additionally DCPIB reverses cell swelling-induced action potential shortening in atrial myocytes and attenuates astrocyte swelling in vitro The compound modulates two-pore domain potassium channels activating TREK1 and TRAAK while inhibiting TRESK TASK1 and TASK3 DCPIB serves as a valuable tool for research on ion channel physiology and cellular volume regulation
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