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Apexbio Technology LLC Decernotinib(VX-509) 944842-54-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B59295.1
Decernotinib (VX-509) is an orally bioavailable inhibitor targeting Janus kinase 3 (JAK3) with additional inhibitory activities toward JAK1 JAK2 and TYK2 (Ki values JAK3 2 nM JAK1 11 nM JAK2 13 nM TYK2 11 nM) Janus kinases are intracellular tyrosine kinases critical for cytokine-mediated signal transmission involved notably in immune cell activation and inflammatory responses By inhibiting JAK-mediated STAT5 phosphorylation VX-509 modulates cytokine-dependent lymphocyte proliferation and activation This compound has been employed in preclinical models exploring therapeutic potential in autoimmune conditions and inflammatory disorders such as rheumatoid arthritis
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