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Apexbio Technology LLC Decitabine (NSC127716, 5AZA-CdR)(Synonyms: 5-Aza-2'-deoxycytidine, 5-Azadeoxycytidine, 5-AZA-dC, DAC, Dacogen, Dezocitidine, NSC 127716, 5-AZA-CdR), 50mg, CAS: 2353-33-5.
Supplier: Apexbio Technology LLC A190650
Decitabine (NSC127716 5AZA-CdR CAS 2353-33-5) is a cytidine analog that regulates gene expression through inhibition of DNA methyltransferases Upon incorporation into DNA during replication it covalently binds to DNA methyltransferase enzymes leading to reduced DNA cytosine methylation Independent of promoter methylation status decitabine alters histone modifications increasing histone H3 lysine 9 acetylation and histone H3 lysine 4 methylation at specific tumor suppressor gene loci thus reactivating transcriptionally silenced genes It is widely used in biomedical research as an epigenetic modulator particularly in the context of hematopoietic malignancies and solid tumors
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