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Medchemexpress LLC DEG-35 | 2734910-37-1 | 98.88% | 443.45 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1729311MG

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DEG-35 is a CRBN-dependent, dual IKZF2 and CK1α molecule glue degrader, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptosis pathway and can be used in research for Acute Myeloid Leukemia (AML).

  • CRBN-dependent dual IKZF2 and CK1α molecule glue degrader
  • Activates the p53 apoptosis pathway
  • Potential for research in Acute Myeloid Leukemia (AML)
  • Induces significant dose-dependent apoptosis and myeloid differentiation in MOLM-13 cells at 10 and 100 nM after 2 days
  • Delays leukemia progression in BL/6 mice transplanted with MLL-AF9 CrbnI391V cells at 50 mg/kg (ip) without overt weight loss

Catalog No. 50-003-85893


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