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Apexbio Technology LLC Denifanstat 1399177-37-7 10mg
Supplier: Apexbio Technology LLC A998510
Denifanstat (CAS 1399177-37-7) also known as TVB-2640 is an orally bioavailable and selective inhibitor of fatty acid synthase (FASN) a critical enzyme involved in lipid biosynthesis in tumor cells By blocking FASN activity Denifanstat impedes endogenous fatty acid production thereby suppressing lipid metabolism essential for cancer cell proliferation The compound demonstrates potent inhibitory activity with an IC50 of 0 052 M for FASN and an EC50 of 0 072 M in cellular assays indicating effective target engagement at low concentrations Currently in clinical investigations Denifanstat is being studied as a novel agent for targeting lipid metabolism in cancer research
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