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Medchemexpress LLC Dermaseptin | 136212-91-4 | 99.7% | 3455.10 | 5 MG
Supplier: Medchemexpress LLC HYP02635MG
Dermaseptin is a peptide isolated from frog skin that exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration. It is a water-soluble, thermostable, and nonhemolytic peptide with highly potent antimicrobial activity against pathogenic fungi at micromolar concentrations.
- Exerts lytic action on bacteria, protozoa, yeasts, and filamentous fungi.
- Mechanism involves an amphipathic alpha-helix perturbing membrane functions.
- Broad spectrum: Inhibits 100% proliferation of most microorganisms (5-100 μg/ml).
- Low in vitro toxicity to human cells, not inhibiting KJ3 cell proliferation or permeating guinea pig lymphocytes.
- Hemolysis of rabbit erythrocytes observed at doses above 200 μg/ml.
- Active against *Aeromonas cauiae*, *Pseudomonas aeroginusa*, *Escherichia coli*, *Enterococcus faecalis*, *L. mezicana*, and *Microsporum canis*.
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