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Medchemexpress LLC Desonide | 638-94-8 | 99.2% | 100 MG
Supplier: Medchemexpress LLC HYB0248100MG
Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. It also specifically binds to the mutant huntingtin protein (mHTT), which helps in reducing the level and toxicity of mHTT. This agent is useful in the research of Huntington's disease and various inflammatory conditions like atopic dermatitis.
- Significantly inhibits mHTT-induced cytotoxicity.
- Reduces apoptotic signals.
- Improves cell survival in striatal cells of HD mice, neurons from HD patients, and Drosophila expressing mHTT.
- Rescues behavioral deficits in Huntington's disease mouse models.
- Lowers mHTT aggregates.
- Partially restores levels of HD molecular biomarkers.
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