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Apexbio Technology LLC Dexrazoxane HCl (ICRF-187, ADR-529) 149003-01-0 100mg
Supplier: Apexbio Technology LLC A1602100
Dexrazoxane HCl (ICRF-187 ADR-529) is a small-molecule inhibitor targeting topoisomerase II It is designed to inhibit topoisomerase II activity and sequester intracellular iron thereby reducing DNA strand cleavage and mitigating iron-dependent oxidative stress Dexrazoxane HCl exerts its biological activity primarily through intracellular iron chelation and inhibition of topoisomerase II which attenuates reactive oxygen species formation and stabilizes DNA structure Based on these pharmacological properties Dexrazoxane HCl holds research potential in investigating cardioprotective strategies particularly against anthracycline-induced cardiotoxicity
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