Medchemexpress LLC diABZI STING agonist-1 | 2138498-18-5 | 99.9% | 849.94 | 10 MG

Supplier:  Medchemexpress LLC HY112921A10MG

diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130 nM and 186 nM for human and mouse, respectively. It is for research use only.

• Selective stimulator of interferon genes (STING) receptor agonist
• EC50s of 130 nM (human STING in PBMCs) and 186 nM (mouse)
• High selectivity against more than 350 kinases tested at 1 μM
• Induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo (subcutaneous injection; 2.5 mg/kg)
• Exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (200 ng/mL) with intravenous injection (3 mg/kg)
• Results in significant tumor growth inhibition and improved survival in mice (intravenous injection; 1.5 mg/kg; 43 days)

Catalog No. 50-004-38815