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Medchemexpress LLC Diltiazem (hydrochloride) | 33286-22-5 | 99.47% | 450.98 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1465610MM/1ML

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Diltiazem hydrochloride is a Ca2+ influx inhibitor, also known as a slow channel blocker or calcium antagonist. Intended for research use only, this benzothiazepine Ca2+ antagonist interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels. It causes a dose-dependent inhibition of contractions and Ca2+ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization.

  • Ca2+ influx inhibitor
  • Slow channel blocker or calcium antagonist
  • Interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels
  • Causes dose-dependent inhibition of contractions and Ca2+ influx
  • Inhibits Na-dependent Ca-efflux from heart mitochondria
  • Improves cardiac microcirculation and function in hyperthyroid rats
  • Decreases blood pressure and increases heart rate in hypertensive rats
  • L-type calcium channel is the IC50 target

Catalog No. 50-003-62569


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