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Medchemexpress LLC Diltiazem hydrochloride | 33286-22-5 | 99.5% | 450.98 | 1 G
Supplier: Medchemexpress LLC HY146561G
Diltiazem hydrochloride is identified as a Ca2+ influx inhibitor, also known as a slow channel blocker or calcium antagonist.
- Interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels.
- Causes a dose-dependent inhibition of contractions and Ca2+ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization.
- Inhibits the Na-dependent Ca-efflux from heart mitochondria.
- Produces noncompetitive inhibition of Ca2+-induced contractions of depolarized rabbit aorta.
- Improves cardiac microcirculation and function in an experimental model of hyperthyroidism in rats.
- Reduces the percentage of fibrosis areas in the left ventricle in hyperthyroid rats.
- Decreases blood pressure and increases heart rate in spontaneously hypertensive rats (SHR).
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