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Apexbio Technology LLC Disulfiram 97-77-8 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A40155.1

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Disulfiram (CAS 97-77-8) is a small molecule compound recognized as a copper ionophore facilitating intracellular transport of Cu ions It inhibits inflammasome-dependent pyroptotic cell death IL-1 secretion and gasdermin D (GSDMD)-mediated pore formation in liposomes within human and murine cellular models Mechanistically disulfiram elevates intracellular reactive oxygen species (ROS) concentrations in the presence of copper initiating copper-dependent cell death Additionally disulfiram disrupts the ubiquitin-proteasome protein degradation pathway in tumor cells impairing cellular waste clearance and inducing apoptosis Research demonstrates its potential anti-cancer activity particularly synergistically enhanced by copper supplementation and cardioprotective effects against ischemia-reperfusion-induced damage

Catalog No. 50-000-64004


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