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Medchemexpress LLC DMAPT (Dimethylamino parthenolide) | 791595-09-0 | 98.0% | 293.40 | 25 MG
Supplier: Medchemexpress LLC 25MGHY16172
DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor with potential anti-cancer and anti-metastatic effects. It has an LD50 of 1.7 μM for cell population in AML cells.
- Oral active NF-κB inhibitor.
- LD50 of 1.7 μM for cell population in AML cells.
- Potential anti-cancer and anti-metastatic effect.
- Decreased constitutive NF-κB binding activity and inhibits cell proliferation and viability of PC-3 and DU145 cells.
- Increases sensitivity of PC-3 tumor xenografts to X-rays in vivo.
- Slows normal tumor development in TRAMP mice.
- Reduces metastatic area in lung tissues of TRAMP mice.
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