Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC DMAT 749234-11-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A33685.1
DMAT (CAS 749234-11-5) known as 2-dimethylamino-4 5 6 7-tetrabromo-benzimidazole is a small-molecule inhibitor primarily targeting protein kinase CK2 with an IC50 of 0 13 M It also inhibits other kinases notably PKD1 PIM3 and PIM1 CK2 is implicated in the regulation of cell proliferation and survival and is frequently overexpressed in various human cancers In cellular models DMAT induces caspase-mediated apoptosis in breast cancer cells resistant to antiestrogens and suppresses steroid hormone secretion and proliferation in adrenocortical carcinoma cells In vivo studies indicate that DMAT interferes with NF B and Wnt signaling pathways and impairs hepatoma cell growth by targeting CK2 and PIM-3 supporting its utility in cancer research
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?