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TARGETMOL CHEMICALS INC DMU-212 25MG
SDP

Supplier:  TARGETMOL CHEMICALS INC T3667425MG

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Also available in 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. DMU-212 is a methylated derivative of resveratrol with antimitotic, anti-proliferative, antioxidant, and apoptosis-promoting activities. It induces mitotic arrest, apoptosis, and activation of ERK1/2 protein and has oral activity[1][2]. DMU-212 (0.3125-40 uM) inhibits the growth of human melanoma cells (A375, MeWo, Bro, M5)[1]. At concentrations of 30-50 uM over 24 hours, it upregulates cell cycle inhibitors, induces apoptosis, and activates ERK in A375 cells[1]. DMU-212 also induces G2/M arrest and apoptosis in cancer cells[1]. In a xenograft model of human ovarian cancer with six-week-old SCID female mice (20-24 g), DMU-212 (50 mg/kg, administered orally three times a week for 14 days) inhibits tumor growth[2]. [1]. Vasilis Pericles Androutsopoulos, et al. 2015 Aug;24(8)632-4. Purity 99.64%

Catalog No. 50-287-8785


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