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Medchemexpress LLC Dnl343 | 2278265-85-1 | 99.9% | 457.83 | 25 MG
Supplier: Medchemexpress LLC 25MGHY149555
DNL343 is a potent, selective, orally active, and brain-penetrant activator of eukaryotic initiation factor eIF2B. It inhibits the integrated stress response (ISR) in the central nervous system (CNS), reversing neurodegeneration and neuroinflammation. It also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice, making it a candidate for studying neurodegenerative diseases.
- Potent, selective, orally active, and brain-penetrant activator of eukaryotic initiation factor eIF2B.
- Inhibits integrated stress response (ISR) activity in the central nervous system (CNS).
- Reverses neurodegeneration and neuroinflammation.
- Prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice.
- Potential for use in neurodegenerative disease studies.
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