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Apexbio Technology LLC Docetaxel Trihydrate 148408-66-6 50mg
Supplier: Apexbio Technology LLC A337050
Docetaxel Trihydrate (CAS 148408-66-6) is a semisynthetic taxane derivative that interferes with cell division by binding to and stabilizing microtubules thereby inhibiting their depolymerization This action disrupts mitotic spindle function leading to cell cycle arrest and apoptosis In vitro studies demonstrate that docetaxel exhibits variable cytotoxicity across cancer cell lines with IC50 values ranging from 0 13 to 3 3 ng/ml Unlike paclitaxel docetaxel-induced gene expression changes are predominantly associated with cell surface receptor-mediated signaling cytokine interactions and cell cycle regulation Docetaxel Trihydrate is widely utilized in oncology research and preclinical models investigating mitotic inhibitors and mechanisms of chemoresistance
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