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Medchemexpress LLC Docosanoic acid | 112-85-6 | 99.40% | 340.59 | 25 G
Supplier: Medchemexpress LLC 25GHYW013049
Docosanoic acid, also known as Behenic acid, is a long-chain saturated fatty acid. It has been observed to inhibit the double-stranded DNA (dsDNA) binding activity of the p53 DNA binding domain, with a Kd of 12 nM. This compound has low bioavailability and can lead to an increase in cholesterol levels in humans.
- Long-chain saturated fatty acid.
- Inhibits dsDNA binding activity of p53 DNA binding domain (Kd = 12 nM).
- 50% inhibition of wild-type p53 DBD observed at 0.41 nmol.
- Inhibitory effect on R248A mutant p53 DBD is similar to wild-type.
- In rats, dietary behenic acid (1.7%) significantly reduces visceral fat deposition, leading to lower adipose and hepatic tissue weight.
- Low bioavailability, leading to reduced absorption and a decrease in body weight and visceral fat deposition in rats.
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