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Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | 200 MG
Supplier: Medchemexpress LLC HYB0034200MG
Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity, demonstrating high selectivity for AChE over BuChE. It also exhibits neuroprotective effects against Aβ42 neurotoxicity. The neuroprotective mechanism involves enhanced phosphorylation of Akt and GSK-3β, and reduced phosphorylation of tau and glycogen synthase. Pharmacokinetic studies showed that Donepezil treatment significantly prevents scopolamine-induced memory impairment in mice.
- Reversible, selective AChE inhibitor
- IC50 of 6.7 nM for AChE activity
- High selectivity for AChE over BuChE
- Exhibits neuroprotective effect on Aβ42 neurotoxicity
- Enhances phosphorylation of Akt and GSK-3β
- Reduces phosphorylation of tau and glycogen synthase
- Significantly prevents scopolamine-induced memory impairment in mice
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