Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | 50 MG
Supplier: Medchemexpress LLC HYB003450MG
Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM, showing high selectivity for AChE over BuChE. It exhibits a neuroprotective effect on Aβ42 neurotoxicity. In vivo, Donepezil treatment prevents the progression of scopolamine-induced memory impairment in mice, demonstrating its potential in neurodegenerative research.
- Reversible, selective AChE inhibitor
- IC50 of 6.7 nM for AChE activity
- High selectivity for AChE over BuChE
- Exhibits a neuroprotective effect on Aβ42 neurotoxicity
- Enhances phosphorylation of Akt and GSK-3β
- Reduces phosphorylation of tau and glycogen synthase
- Increases cell viability in cortical neuronal cells
- Prevents scopolamine-induced memory impairment in mice
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?