Medchemexpress LLC Doxercalciferol (1.alpha.-hydroxyvitamin D2) | 54573-75-0 | 99.9% | 412.65 | 100 MG

Supplier:  Medchemexpress LLC HY32348100MG

Doxercalciferol is a Vitamin D2 analog that acts as an activator of the Vitamin D receptor and helps prevent renal disease.

• Vitamin D2 analog
• Activator of vitamin D receptor
• Helps prevent renal disease
• Elevates serum phosphorus, calcium, and Ca x P in 5/6 nephrectomized rats
• Blocks PTH from rising and lowers serum PTH
• Improves proteinuria, prevents podocyte loss, and accumulation of extracellular matrix proteins in HF diet-induced mice
• Inhibits profibrotic growth factors (TGF-β, PAI-1, CTGF)
• Suppresses macrophage infiltration, decreases NF-κb activity, and prevents expression of proinflammatory cytokine and renal lipid accumulation
• Prevents albuminuria, attenuates podocyte loss and apoptosis, and reduces glomerular fibrosis in diabetic mice

Catalog No. 50-004-00659