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Apexbio Technology LLC Doxycycline hyclate 24390-14-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A40525.1
Doxycycline hyclate is a semisynthetic antibiotic derivative of tetracycline exhibiting antibacterial antiviral and anti-inflammatory activities It functions primarily as an inhibitor of matrix metalloproteinases (MMPs) notably reducing expression and activity of MMP-2 MMP-8 and MMP-9 thus applicable in research involving inflammatory conditions and vascular pathologies such as intracranial aneurysms Its antiviral properties include inhibition of dengue virus replication by targeting viral NS2B-NS3 serine protease experimental conditions at 37 C and 40 C yielded IC50 values of 52 3 M and 26 7 M respectively Additionally doxycycline hyclate demonstrates antimalarial activity with in vivo experiments showing an IC50 of 320 nM at 96 hours facilitating potential use in parasitology research models
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