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Cayman Chemical dPE-PEG 2000 MaleImIde 25mg
SDP

Supplier:  Cayman Chemical 4201325 MG

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A MDM2-p53 protein-protein interaction inhibitor (IC50 0.21 nM) selectively inhibits the MDM2-p53 protein-protein interaction over MDM4-p53 YAP1-TEAD4 PCSK9-LDLR and Bcl-2-Bak interactions in TR-FRET assays (IC50s 3.3 150 50 and 50 UM respectively) inhibits the growth of SJSA-1 cells (GI50 38 nM) induces apoptosis in SJSA-1 cells at 100 nM induces tumor regression and prevents tumor regrowth in an SJSA-1 rat xenograft model and an HSAX2655 PDX rat liposarcoma model at 27 mg/kg

Catalog No. 50-294-3114


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