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Medchemexpress LLC Dronedarone (hydrochloride) | 141625-93-6 | 99.99% | C31H45ClN2O5S | 500 MG
Supplier: Medchemexpress LLC HY75839500MG
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+, and Ca2+ currents. It serves as a multichannel blocker for atrial fibrillation, demonstrating various inhibitory effects on ion channels and biological activities.
- Inhibits Na+, K+, and Ca2+ currents
- Potent inhibitor of acetylcholine-activated K+ current
- Blocks IKr (IC50=3 μM) and ICa-L (IC50=0.18 μM)
- Reduces the incidence of ventricular fibrillation in rats
- Inhibits carotid artery thrombus formation
- Impairs thrombin- and collagen-induced platelet aggregation
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