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Medchemexpress LLC Dronedarone Hydrochloride | 141625-93-6 | MFCD00947708 | 99.99% | C31H45ClN2O5S | 1 ML
Supplier: Medchemexpress LLC HY7583910MM/1ML
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents. It acts as a multichannel blocker for atrial fibrillation, potently inhibiting acetylcholine-activated K+ currents and rapid delayed rectifier K+ currents.
- Inhibits Na+, K+, and Ca2+ currents
- Acts as a multichannel blocker for atrial fibrillation
- Potently inhibits acetylcholine-activated K+ current
- Inhibits rapid delayed rectifier and L-type calcium currents
- Blocks IKr and ICa-L
- Exhibits state-dependent inhibition of fast Na+ channel current
- Significantly reduces incidence of ventricular fibrillation
- Inhibits carotid artery thrombus formation in vivo
- Impairs thrombin- and collagen-induced platelet aggregation
- Reduces expression of plasminogen activator inhibitor-1 (PAI1)
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