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Medchemexpress LLC DSPE-PEG4-DBCO | 2112738-14-2 | 95.0% | C71H116N3O15P | 100 MG
Supplier: Medchemexpress LLC HY140955100MG
DSPE-PEG4-DBCO is a PEG-based PROTAC linker employed in the synthesis of PROTACs. It serves as a click chemistry reagent, incorporating a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This mechanism leverages the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables SPAAC with azide-containing molecules
- Leverages the ubiquitin-proteasome system
- Achieves selective protein degradation
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