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Apexbio Technology LLC DUBs-IN-2 924296-19-5 2mg
Supplier: Apexbio Technology LLC B35152
DUBs-IN-2 (CAS 924296-19-5) is a small molecule inhibitor of deubiquitinating enzymes USP7 and USP8 identified from high-throughput screening of 65 902 chemical entities It inhibits USP7 and USP8 with IC50 values of 7 2 M and 0 93 M respectively as determined using a ubiquitin-AMC cleavage assay in purified recombinant enzyme systems USP7 is involved in modulating the stability of tumor suppressor p53 as well as interacting with cellular and viral regulatory proteins while USP8 participates in pathways regulating epidermal growth factor receptor signaling and receptor trafficking DUBs-IN-2 serves as a useful tool for investigating the roles of USP7 and USP8 in ubiquitin-mediated cellular processes and their implications in disease-related pathways
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