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Apexbio Technology LLC Dutasteride 164656-23-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A16595.1
Dutasteride (CAS 164656-23-9) is a dual inhibitor of 5-alpha-reductase isoforms 1 and 2 enzymes responsible for the conversion of testosterone to dihydrotestosterone (DHT) In LNCaP prostate cancer cells Dutasteride suppresses over 99% of 3H-testosterone to 3H-DHT transformation and reduces cell proliferation and viability Treatment with Dutasteride for 48 hours induces caspase 7 and caspase 8 activity in a dose-dependent manner supporting its impact on apoptotic and survival pathways In vivo Dutasteride blocks the initiation and progression of prostate cancer in transgenic mouse models This compound is widely utilized in studies of androgen signaling and prostate disease pathology
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