Medchemexpress LLC DYRKs-IN-1 hydrochloride | 1386980-55-7 | 99.7% | 50 MG

Supplier:  Medchemexpress LLC HY128758A50MG

DYRKs-IN-1 hydrochloride is a highly potent inhibitor of Dual-specificity tyrosine-phosphorylation-regulated kinases (DYRKs). It demonstrates significant inhibitory activity against DYRK1A and DYRK1B, with IC50 values of 5 nM and 8 nM, respectively. This compound also exhibits notable antitumor activity. Specifically, in vitro studies have shown that DYRKs-IN-1 hydrochloride (referred to as compound 30) enhances the cellular potency against the human colon tumor cell line SW 620, with an EC50 of 27 nM. It is recognized as a potent DYRKs inhibitor.

• Potent inhibitor of Dual-specificity tyrosine-phosphorylation-regulated kinases (DYRKs).
• Targets DYRK1A with an IC50 of 5 nM.
• Targets DYRK1B with an IC50 of 8 nM.
• Demonstrates antitumor activity.
• Increases cellular potency against human colon tumor cell line SW 620 with an EC50 of 27 nM.

Catalog No. 50-003-39641