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Apexbio Technology LLC E-64-c(Synonyms: E-64c, Epoxysuccinyl peptide derivative E-64-c, trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane), 10mM (in 1mL DMSO), CAS: 76684-89-4.
Supplier: Apexbio Technology LLC A81625.1
E-64-c (CAS 76684-89-4) also referred to as Ep-475 is an analog of E-64 and functions as a cysteine protease inhibitor It inhibits mammalian cysteine proteases notably cathepsins B H and L by covalently binding to their active site sulfhydryl groups Compared to E-64 E-64-c exhibits significantly higher inhibitory potency for cathepsins B and L with inactivation rate constants of 2 98 10 5 M -1s -1 and 2 06 10 5 M -1s -1 respectively Research applications demonstrated that E-64-c reduces cysteine protease-mediated protein degradation including reducing muscle proteolysis in burned rats and ischemic cerebral protein breakdown in rodent stroke models
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