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Medchemexpress LLC (E)-Osmundacetone | 123694-03-1 | 178.19 | 5 MG
Supplier: Medchemexpress LLC HYN19665MG
(E)-Osmundacetone is an inhibitor of the MAPK pathway. It inhibits the activation of the MAPK signaling pathway and restores the expression of PPARα/ACOX1. It abrogates abnormal cell proliferation, migration, and liver metastasis induced by PTPRO silencing in colorectal cancer cells. It also blocks OA-RD17-mediated activation of the MAPK signaling pathway, thereby reducing macrophage proliferation and migration. It is applicable to relevant research on colorectal cancer.
- Inhibits the MAPK pathway.
- Restores the expression of PPARα/ACOX1.
- Enhances fatty acid oxidation (FAO).
- Reverses the promotion of proliferation, migration, and liver metastasis in PTPRO-silenced SW480 and LoVo colorectal cancer (CRC) cells.
- Blocks enhanced proliferation and migration of RAW264.7 macrophages induced by OA-RD17.
- Significantly suppresses the up-regulation of miR-632 by OA-RD17 in keratinocytes.
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