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Medchemexpress LLC (E/Z)-Zotiraciclib | 937270-47-8 | C23H24N4O | 1 ML
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Supplier:  Medchemexpress LLC HY1516610MM/1ML

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(E/Z)-Zotiraciclib is a potent inhibitor of CDK2, JAK2, and FLT3, with IC50s of 13, 73, and 56 nM, respectively. It effectively inhibits the proliferation of cancer cells and is intended for cancer research.

  • Potent inhibitor of CDK2, JAK2, and FLT3
  • Inhibits proliferation of cancer cells including HL-60, HCT-116, RAMOS, COLO205, and DU145
  • Potently inhibits the CDK2 biomarker pRb in HCT-116 and MV4-11 cells
  • Demonstrates significant tumor growth inhibition in HCT-116 colon cancer cell xenografts (82% TGI)
  • Inhibits tumor growth in lymphoma Ramos cells xenografts (42% oral, 63% intraperitoneal TGI)

Catalog No. 50-003-73164


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