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Apexbio Technology LLC Edoxaban tosylate monohydrate 1229194-11-9 10mg
Supplier: Apexbio Technology LLC A338310
Edoxaban tosylate monohydrate (CAS 1229194-11-9) is a small-molecule oral anticoagulant that selectively and directly inhibits coagulation factor Xa (FXa) a serine protease central to the thrombin generation pathway In vitro edoxaban tosylate monohydrate demonstrates high affinity for free FXa (Ki 0 561 nM) and the prothrombinase complex (Ki 2 98 nM) with over 10 000-fold selectivity for FXa versus related targets It effectively prolongs prothrombin time and activated partial thromboplastin time in human plasma without affecting platelet aggregation induced by ADP collagen or U46619 In vivo it exhibits dose-dependent inhibition of thrombosis in rodent models with minimal prolongation of bleeding time Edoxaban tosylate monohydrate is widely used in thrombosis and anticoagulation research
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