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Apexbio Technology LLC Edrophonium (chloride) 116-38-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC C41405.1
Edrophonium chloride (CAS 116-38-1) is a small-molecule inhibitor targeting acetylcholinesterase (AChE) an essential enzyme involved in terminating acetylcholine-mediated signal transduction by rapid hydrolysis at neuronal synapses Edrophonium competitively inhibits AChE elevating acetylcholine concentrations and altering neurotransmission dynamics In vitro studies report its inhibition potency (Ki) against human erythrocyte calf forebrain and octopus brain AChE as 0 2 0 2 and 0 4 M respectively Experimentally intravenous edrophonium administration in humans has been utilized to provoke esophageal chest discomfort and to study neuromuscular blockade reversal pharmacodynamics highlighting its importance in biomedical and clinical research contexts
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