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Apexbio Technology LLC EG00229(Synonyms: EG00229, Nrp1 inhibitor, Neuropilin-1 inhibitor, EG-00229, Nrp-1 inhibitor), 5mg, CAS: 1210945-69-9.
Supplier: Apexbio Technology LLC B46575
EG00229 (CAS 1210945-69-9) is a small molecule inhibitor targeting neuropilin-1 (Nrp1) It disrupts the binding between vascular endothelial growth factor-A (VEGF-A) and the Nrp1 receptor inhibiting interactions involving purified Nrp1 and Nrp1-expressing PAE cells with IC50 values of approximately 3 M and 8 M respectively EG00229 also inhibits VEGF-A interaction with Nrp1 VEGFR1 and VEGFR2 in human umbilical vein endothelial cells (HUVECs) Additionally it impairs tuftsin-mediated activation of Nrp1 consequently blocking tuftsin-induced anti-inflammatory M2 polarization in microglia This compound is valuable for investigating Nrp1 s role in angiogenesis and inflammation
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