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Apexbio Technology LLC EI1 1418308-27-6 25mg
Supplier: Apexbio Technology LLC B102125
EI1 (CAS 1418308-27-6) is a potent and selective small-molecule inhibitor of the histone methyltransferase Ezh2 demonstrating IC50 values of 15 nM against wild-type Ezh2 and 13 nM for the Y641F mutant Ezh2 is implicated in oncogenesis through epigenetic silencing of tumor suppressor genes and is frequently upregulated or mutated in various cancers In cellular studies EI1 inhibits H3K27 methylation and induces expression of Ezh2 target genes such as p16 It effectively impedes the proliferation of DLBCL cells particularly those harboring EZH2 mutations leading to cell cycle arrest and apoptosis EI1 is widely used to investigate Ezh2 function and its role in cancer biology
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