ABclonal Technology EIF4G2/p97 Rabbit mAb

Supplier:  ABclonal Technology A21193100UL

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F) which is a cap binding protein complex that consists of three subunits eIF4A eIF4E and eIF4G The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3 eIF4G in addition contains a binding site for eIF4E at the N-terminus Unlike eIF4G which supports cap-dependent and independent translation this gene product functions as a general repressor of translation by forming translationally inactive complexes In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon Alternatively spliced transcript variants encoding different isoforms of this gene have been described

Catalog No. 50-000-07651