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Medchemexpress LLC Elimusertib hydrochloride | 99.9% | 411.89 | 100 MG
Supplier: Medchemexpress LLC 100MGHY101566A
Elimusertib hydrochloride (BAY 1895344) is a potent, orally active, and selective ATR inhibitor with an IC50 of 7 nM. It demonstrates anti-tumor activity and can be used for research on solid tumors and lymphomas.
- Potent, orally active, and selective ATR inhibitor
- Demonstrates anti-tumor activity
- Applicable for research on solid tumors and lymphomas
- Inhibits proliferation of human tumor cell lines
- Suppresses hydroxyurea-induced H2AX phosphorylation
- Shows good selectivity against related kinases
- Potent antiproliferative activity against various cancer cell lines in vitro
- Potent anti-tumor efficacy in monotherapy in xenograft models
- Causes complete tumor remission in mantle cell lymphoma models
- Synergistic antitumor activity with Carboplatin in relevant models
- Exhibits moderate oral bioavailability
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