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BioVendor, LLC IGFBP-2 Mouse/Rat ELISA (96 wells)

Supplier: BioVendor, LLC E08

IGFBP-2 Mouse/Rat ELISA (96 wells). Enzyme immunoassay kit to measure Insulin-Like Growth Factor Binding Protein-2 in mouse or rat serum. QC control included. SAMPLE REQ 10 l/well. CALIBRATION RANGE: 0.0312 ng/ml. ASSAY RANGE: 0.01 200 ng/mL. DETECTION LIMIT: 0.01 ng/ml. SUMMARY: IGFBP2 (IBP2, IBP-2) seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism. IGFBP2 shows no circadian rhythm in circulation. Serum concentration of IGFBP2 increases in fasting, and after major surgery or trauma; the greatest increases are in malignant diseases. In various tumor types IGFBP2 level increases with degree of progression, with normalization after remission. IGFBP2 level decreases during GH-therapy. The ratio IGFBP2:IGFBP1 is a marker for the Trisomy 18 chromosome abnormality. Over expression of the IGFBP2 gene in mice results in 30% weight reduction in spleen and moderately reduced weight in other organs. Manufactured by Mediagnost GmbH, Germany.
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