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Medchemexpress LLC Ellagic acid | 476-66-4 | 1 G
Supplier: Medchemexpress LLC HYB01831G
Ellagic acid is a natural antioxidant that acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC50 of 40 nM and a Ki of 20 nM. This compound also blocks other kinases such as LYN, PKA, SYK, GSK3, FGR, and CK1.
- Acts as a natural antioxidant
- Functions as a potent and ATP-competitive inhibitor of CK2 and SHP2
- Blocks various other kinases including LYN, PKA, SYK, GSK3, FGR, and CK1
- Exhibits inhibitory activities against Karpas299, SUDHL1, SR786, and FE-PD cell lines
- Shows cytotoxic effects on MCF-7 cells after radiation treatment
- Induces cell apoptosis in MCF-7 cells when combined with irradiation
- Decreases MDA brain content and reduces brain TNF-α levels in rats
- Increases brain contents of 5-HT, dopamine, and norepinephrine in rats
- Reduces histopathological changes induced by Doxorubicin in rats
- Supported by over 20 cited publications
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