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Medchemexpress LLC Eln318463 racemate | 851599-82-1 | >98% | C19H20BrClN2O3S | 50 MG
Supplier: Medchemexpress LLC HY5088250MG
ELN318463 racemate is a selective γ-secretase inhibitor, demonstrating differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase. It shows significant selectivity for PS1 with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. This compound acts as a classic γ-secretase inhibitor, inhibiting Aβ production with 75- to 120-fold selectivity over Notch signaling in cells.
- Amyloid precursor protein (APP) selective γ-secretase inhibitor
- Differentially inhibits presenilin (PS1) and PS2-comprised γ-secretase
- 51-fold more selective for PS1
- Demonstrates 75- to 120-fold selectivity for inhibiting Aβ production
- Displaces an active site-directed inhibitor in the presence of a substrate
- Achieves brain levels up to 2.7 μM at 100 mg/kg dose
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