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Apexbio Technology LLC ELR510444 1233948-35-0 10mg
Supplier: Apexbio Technology LLC B587010
ELR510444 (CAS 1233948-35-0) is a small-molecule microtubule disruptor currently in preclinical development It acts by binding the colchicine site on tubulin interfering with microtubule polymerization In vitro ELR510444 induces microtubule depolymerization disrupts mitotic spindle formation and leads to mitotic arrest and apoptosis in cancer cells The compound has been shown to competitively displace colchicine from purified tubulin and inhibit cell proliferation In vivo ELR510444 demonstrated antitumor activity in the MDA-MB-231 xenograft model with an expanded therapeutic window It is under investigation for its potential as an anticancer agent and as a tool for microtubule biology research
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