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Medchemexpress LLC ELR510444 | 1233948-35-0 | 98.0% | 368.47 | 25 MG
Supplier: Medchemexpress LLC 25MGHY16191
ELR510444 is a novel microtubule disruptor that inhibits MDA-MB-231 cell proliferation and exhibits potent antitumor activity. It is not a substrate for the P-glycoprotein drug transporter, maintaining activity in βIII-tubulin-overexpressing cell lines, thereby circumventing drug resistance. This compound also shows potential antivascular effects by decreasing HIF-1α and HIF-2α levels, reducing renal cell carcinoma (RCC) cell viability and clonogenic survival, and inducing apoptosis to significantly reduce tumor burden in RCC xenograft models. For research use only.
- Inhibits MDA-MB-231 cell proliferation with an IC50 of 30.9 nM
- Circumvents drug resistance mechanisms by not being a P-glycoprotein substrate
- Demonstrates potent antitumor activity in MDA-MB-231 xenograft model
- Exhibits potential antivascular effects
- Reduces renal cell carcinoma (RCC) cell viability and induces apoptosis
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